The contribution of CK2 and spleen tyrosine kinase (SYK) to CFTR trafficking and PKA-induced activity

Previously, the pleiotropic “master kinase” casein kinase 2 (CK2) was shown to interact with CFTR, the protein responsible for cystic fibrosis (CF). Moreover, CK2 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts, and Xenopus oocytes. CFTR possesses two...

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Bibliographic Details
Main Author: Luz, Simão (author)
Other Authors: Kongsuphol, Patthara (author), Mendes, Ana Isabel (author), Romeiras, Francisco (author), Sousa, Marisa (author), Schreiber, Rainer (author), Matos, Paulo (author), Jordan, Peter (author), Mehta, Anil (author), Amaral, Margarida D. (author), Kunzelmann, Karl (author), Farinha, Carlos M. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Vias de Transdução de Sinal e Patologias Associadas
Cystic Fibrosis
Syk
Casein Kinase
Online Access:http://hdl.handle.net/10400.18/907
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/907

Internet

http://hdl.handle.net/10400.18/907

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