Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1

Kinesins are a superfamily of microtubule-based molecular motors that perform various transport needs and have essential roles in cell division. Among these, the kinesin-5 family has been shown to play a major role in the formation and maintenance of the bipolar mitotic spindle. Moreover, recent wor...

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Bibliographic Details
Main Author: Maia, AF (author)
Other Authors: Tanenbaum, ME (author), Galli, M (author), Lelieveld, D (author), Egan, DA (author), Gassmann, R (author), Sunkel, CE (author), den, Heuvel, S (author), Medema, RH (author)
Format: article
Language:eng
Published: 2015
Subjects:
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins/genetics
Caenorhabditis elegans Proteins/metabolism
Genes, Lethal
Genome, Helminth
Kinesin/genetics
Kinesin/metabolism
Microtubule-Associated Proteins/genetics
Microtubule-Associated Proteins/metabolism
RNA Interference
Signal Transduction
Spindle Apparatus
Online Access:http://hdl.handle.net/10216/114508
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114508

Internet

http://hdl.handle.net/10216/114508

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