Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression

Brain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from de...

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Bibliographic Details
Main Author: Pinheiro, António Mateus (author)
Other Authors: Patrício, P. (author), Bessa, J. M. (author), Sousa, Nuno (author), Pinto, Luísa (author)
Format: article
Language:eng
Published: 2013
Subjects:
antidepressants
cell genesis
depression
neuroplasticity
stress
Science & Technology
Online Access:http://hdl.handle.net/1822/25059
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/25059
Description
Summary:Brain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from depressive-like behavior. However, the neurobiological significance of neuroplastic phenomena in this context is still controversial. Here we summarize recent developments in this topic and propose an integrative interpretation of data gathered so far.

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