Virtual screening of thieno[3,2-b]pyridine arylthioether (hetero)aryltriazole derivatives as potential tyrosine kinase VEGFR2 inhibitors.

Recently we presented a series of thieno[3,2-d]pyrimidinc ether I ,3-diaryl ureas with potent VEGFR2 inhibit ion activity. The binding mode was analyzed and the compounds showed a type-11 tyrosine kinase inhibition mode, with the thienopyrimidine moiety forming a Hydrogen Bond (H-bond) with CYS919 r...

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Bibliographic Details
Main Author: Calhelha, Ricardo C. (author)
Other Authors: Begouin, Agathe (author), Campos, Joana F. (author), Ferreira, Isabel C.F.R. (author), Queiroz, Maria João R.P. (author), Abreu, Rui M.V. (author)
Format: conferenceObject
Language:eng
Published: 2014
Online Access:http://hdl.handle.net/10198/9475
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/9475

Internet

http://hdl.handle.net/10198/9475

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