Dynamic phylogenetic inference for sequence-based typing data

Typing methods are widely used in the surveillance of infectious diseases, outbreaks investigation and studies of the natural history of an infection. And their use is becoming standard, in particular with the introduction of High Throughput Sequencing (HTS). On the other hand, the data being genera...

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Bibliographic Details
Main Author: Francisco, Alexandre (author)
Other Authors: Nascimento, Marta (author), Vaz, Cátia (author)
Format: conferenceObject
Language:eng
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10400.21/9813
Country:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/9813
Description
Summary:Typing methods are widely used in the surveillance of infectious diseases, outbreaks investigation and studies of the natural history of an infection. And their use is becoming standard, in particular with the introduction of High Throughput Sequencing (HTS). On the other hand, the data being generated is massive and many algorithms have been proposed for phylogenetic analysis of typing data, such as the goeBURST algorithm. These algorithms must however be run whenever new data becomes available starting from scratch. We address this issue proposing a dynamic version of goeBURST algorithm. Experimental results show that this new version is efficient on integrating new data and updating inferred evolutionary patterns, improving the update running time by at least one order of magnitude.