The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease

Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is the most common autosomal dominantly-inherited ataxia worldwide and is characterised by the accumulation of mutant ataxin-3 (mutATXN3) in different brain regions, leading to neurodegeneration. Currently, there are no available...

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Detalhes bibliográficos
Autor principal: Vasconcelos-Ferreira, Ana (author)
Outros Autores: Carmo-Silva, Sara (author), Codêsso, José Miguel Antunes (author), Silva, Patrick Joel da (author), Martinez, Alberto Rolim Muro (author), França, Marcondes Cavalcante (author), Nóbrega, Clévio David Rodrigues (author), Almeida, Luís Pereira de (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Machado-Joseph disease
Ataxin-3
Autophagy
Carbamazepine
Neuroprotection
Texto completo:http://hdl.handle.net/10316/96433
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/96433

Texto Completo

http://hdl.handle.net/10316/96433

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