Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in indepe...

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Bibliographic Details
Main Author: Martins, M (author)
Other Authors: Williams, A H (author), Comeau, M (author), Marion, M (author), Ziegler, J T (author), Freedman, B I (author), Merrill, J T (author), Glenn, S B (author), Kelly, J A (author), Sivils, K M (author), James, J A (author), Guthridge, J M (author), Alarcón-Riquelme, M E (author), Bae, S-C (author), Kim, J-H (author), Kim, D (author), Anaya, J-M (author), Boackle, S A (author), Criswell, L A (author), Kimberly, R P (author), Alarcón, G S (author), Brown, E E (author), Vilá, L M (author), Petri, M A (author), Ramsey-Goldman, R (author), Niewold, T B (author), Tsao, B P (author), Gilkeson, G S (author), Kamen, D L (author), Jacob, C O (author), Stevens, A M (author), Gaffney, P M (author), Harley, J B (author), Langefeld, C D (author), Fesel, C (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adult
Antigens, CD3
Asian Continental Ancestry Group
Case-Control Studies
European Continental Ancestry Group
Female
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Lupus Erythematosus, Systemic
Male
Polymorphism, Single Nucleotide
T-Lymphocytes
Online Access:http://hdl.handle.net/10400.7/678
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/678

Internet

http://hdl.handle.net/10400.7/678

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