An integrative system biology approach to delineate complex genotype-phenotype associations in Autism Spectrum Disorder

Objectives: The global objective of the study is to improve the current knowledge on ASD prognosis and diagnosis by delineating the complex genotype-phenotype associations using an integrative systems biology approach. For this purpose three specific objectives were pursued: - To identify clinically...

ver descrição completa

Detalhes bibliográficos
Autor principal: Asif, M. (author)
Outros Autores: Martiniano, Hugo F. (author), Rasga, Célia (author), Marques, Ana R. (author), Santos, João X. (author), Couto, Francisco M. (author), Vicente, Astrid M. (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2017
Assuntos:
Autism Spectrum Disorder
Perturbações do Desenvolvimento Infantil e Saúde Mental
Autismo
Texto completo:http://hdl.handle.net/10400.18/4851
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/4851
Descrição
Resumo:Objectives: The global objective of the study is to improve the current knowledge on ASD prognosis and diagnosis by delineating the complex genotype-phenotype associations using an integrative systems biology approach. For this purpose three specific objectives were pursued: - To identify clinically similar subgroups of individuals with ASD; - To find biological processes disrupted by rare CNVs targeting brain genes in ASD subjects; - To train a machine learning classifier for the clinical prediction of disease progression from genetic information in very young children.

Registos relacionados