On similarities in infrared spectra of complex drugs

A chromatographic separation of active ingredients of Combivir, Epivir, Kaletra, Norvir, Prezista, Retrovir, Trivizir, Valcyte, and Viramune is performed on thin layer chromatography. The spectra of these nine drugs were recorded using the Fourier transform infrared spectroscopy. This information is...

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Bibliographic Details
Main Author: Machado, J. A. Tenreiro (author)
Other Authors: Baleanu, Dumitru (author), Al-Zhrani, Abdulrahim A. (author), Alhamed, Yahia A. (author), Zahid, Adnan H. (author), Youssef, Tamer E. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10400.22/5472
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/5472
Description
Summary:A chromatographic separation of active ingredients of Combivir, Epivir, Kaletra, Norvir, Prezista, Retrovir, Trivizir, Valcyte, and Viramune is performed on thin layer chromatography. The spectra of these nine drugs were recorded using the Fourier transform infrared spectroscopy. This information is then analyzed by means of the cosine correlation. The comparison of the infrared spectra in the perspective of the adopted similarity measure is possible to visualize with present day computer tools, and the emerging clusters provide additional information about the similarities of the investigated set of complex drugs.