Activation of RAC1/PAK1 axis potentiates transcriptional upregulation of DNA damage response genes via the BCL6/STAT5 switch

Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resu...

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Detalhes bibliográficos
Autor principal: Barros, Patrícia (author)
Outros Autores: Amaral, Andreia (author), Abrantes, Leonor (author), Oliveira, Tiago (author), Lourio, Henriqueta (author), Silva, Maria João (author), Jordan, Peter (author), Gama-Carvalho, Margarida (author), Matos, Paulo (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2018
Assuntos:
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
RAC1
Reparação do DNA
Texto completo:http://hdl.handle.net/10400.18/5199
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5199
Descrição
Resumo:Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.

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