Fine time scaling of purifying selection on human nonsynonymous mtDNA mutations based on the worldwide population tree and mother-child pairs

A high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large popul...

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Detalhes bibliográficos
Autor principal: Cavadas, Bruno (author)
Outros Autores: Soares, Pedro (author), Camacho, Rui (author), Brandão, Andreia (author), Costa, Marta D (author), Fernandes, Verónica (author), Pereira, Joana B (author), Rito, Teresa S (author), Samuels, David C (author), Pereira, Luisa (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
mtDNA
Worldwide phylogenetic tree
Mother–child pairs
Massive parallel sequencing
Heteroplasmy
Ciências Naturais::Ciências Biológicas
Science & Technology
Texto completo:http://hdl.handle.net/1822/40675
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40675

Texto Completo

http://hdl.handle.net/1822/40675

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