Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is...

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Detalhes bibliográficos
Autor principal: Pinheiro, António Mateus (author)
Outros Autores: Pinto, Luísa (author), Bessa, J. M. (author), Morais, Mónica (author), Alves, N. D. (author), Monteiro, S. (author), Patrício, P. (author), Almeida, O. F. X. (author), Sousa, Nuno (author)
Formato: article
Idioma:eng
Publicado em: 2013
Assuntos:
Antidepressant
Depression
Gliogenesis
Neurogenesis
Stress
Science & Technology
Texto completo:http://hdl.handle.net/1822/24154
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/24154
Descrição
Resumo:Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.

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