Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies

Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) met...

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Bibliographic Details
Main Author: Vojtek, Martin (author)
Other Authors: Pinto, Edgar (author), Gonçalves-Monteiro, Salomé (author), Almeida, Agostinho (author), Marques, M. P. M. (author), Mota-File, Hélder (author), Ferreira, Isabel M. P. L. V. O. (author), Diniz, Carmen (author)
Format: article
Language:eng
Published: 2021
Subjects:
ICP-MS
Pharmacokinetic
Animal
Palladium
Online Access:http://hdl.handle.net/10400.22/16535
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/16535
Description
Summary:Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).

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