Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycl...

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Bibliographic Details
Main Author: Rossato, Luciana Grazziotin (author)
Other Authors: Costa, Vera Marisa (author), Dallegrave, Eliane (author), Arbo, Marcelo (author), Silva, Renata (author), Ferreira, Rita (author), Amado, Francisco (author), Dinis-Oliveira, Ricardo Jorge (author), Duarte, José Alberto (author), Bastos, Maria de Lourdes (author), Palmeira, C. M. (author), Remião, Fernando (author)
Format: article
Language:eng
Published: 2014
Subjects:
Mitoxantrone
Cardiotoxicity
Mitochondria
Online Access:http://hdl.handle.net/10316/25533
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25533

Internet

http://hdl.handle.net/10316/25533

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