T-20 and T-1249 HIV fusion inhibitors’ structure and conformational behavior in solution: a molecular dynamics study

Fusion of the HIV envelope with the target cell membrane is a critical step of HIV entry into the target cell. Several peptides based on the C-region of HIV gp41 have been used in clinical trials as possible HIV fusion inhibitors. Among these are T-1249 and T-20 (also known as enfurvitide; see fig....

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Bibliographic Details
Main Author: Canto, A. M. T. M. (author)
Other Authors: Palace Carvalho, A. J. (author), Prates Ramalho, J. P. (author)
Format: lecture
Language:eng
Published: 2008
Subjects:
AIDS
HIV fusion inhibitor
enfurvitide
T-20
T-1249
molecular dynamics
molecular simulations
Online Access:http://hdl.handle.net/10174/1191
Country:Portugal
Oai:oai:dspace.uevora.pt:10174/1191

Internet

http://hdl.handle.net/10174/1191

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