TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish

Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding...

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Bibliographic Details
Main Author: Reverendo, Marisa (author)
Other Authors: Soares, Ana R. (author), Pereira, Patrícia M. (author), Carreto, Laura (author), Ferreira, Violeta (author), Gatti, Evelina (author), Pierre, Philippe (author), Moura, Gabriela R. (author), Santos, Manuel A. (author)
Format: article
Language:eng
Published: 2020
Subjects:
tRNA
mRNA mistranslation
Proteotoxic stress
Protein aggregation
ROS
Zebrafish
Online Access:http://hdl.handle.net/10773/27840
Country:Portugal
Oai:oai:ria.ua.pt:10773/27840

Internet

http://hdl.handle.net/10773/27840

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