A review on metabolomics data analysis for cancer applications

Cancer cells undergo metabolic changes that contribute to tumorigenesis, which can be determined using metabolomics data produced by techniques such as nuclear magnetic resonance and mass spectroscopy, and analyzed through statistical and machine learning methods. Since these data represent well the...

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Bibliographic Details
Main Author: Cardoso, Sara (author)
Other Authors: Baptista, Delora (author), Santos, R. (author), Rocha, Miguel (author)
Format: conferencePaper
Language:eng
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/1822/56378
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/56378
Description
Summary:Cancer cells undergo metabolic changes that contribute to tumorigenesis, which can be determined using metabolomics data produced by techniques such as nuclear magnetic resonance and mass spectroscopy, and analyzed through statistical and machine learning methods. Since these data represent well the metabolic phenotype of these cells, they are very relevant in cancer research, to better understand tumour cells metabolism and help in efforts of biomarker and drug target discovery. This mini-review focuses on data analysis methods that are commonly used to extract knowledge from cancer metabolomics data, such as univariate analysis and supervised and unsupervised multivariate data analysis, including clustering and machine learning.