Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one
The pH-independent, acid-catalyzed and base-catalyzed hydrolyses of N-acyloxymethylazetidin-2-ones all occur at the ester function. The pH-independent hydrolysis involves rate-limiting alkyl C-O fission and formation of an exocyclic beta-lactam iminum ion. This iminium ion is then trapped by water a...
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| Other Authors: | , , |
| Format: | article |
| Language: | eng |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10451/21169 |
| Country: | Portugal |
| Oai: | oai:repositorio.ul.pt:10451/21169 |