Injectable gellan gum-based hydrogels for intervertebral disc regeneration

Intervertebral disc (IVD) degeneration is a challenging pathology that, due to the inefficiency of the current treatments, urgently demands for the development of new regenerative approaches[1]. The best viable implant material for nucleus pulposus (NP) regeneration has yet to be identified, but it...

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Bibliographic Details
Main Author: Silva-Correia, Joana (author)
Other Authors: Oliveira, Joaquim M. (author), Caridade, S. G. (author), Oliveira, J. T. (author), Sousa, R. A. (author), Mano, J. F. (author), Reis, R. L. (author)
Format: article
Language:eng
Published: 2011
Subjects:
Gellan gum
Intervertebral
Online Access:http://hdl.handle.net/1822/12795
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/12795
Description
Summary:Intervertebral disc (IVD) degeneration is a challenging pathology that, due to the inefficiency of the current treatments, urgently demands for the development of new regenerative approaches[1]. The best viable implant material for nucleus pulposus (NP) regeneration has yet to be identified, but it is believed that biodegradable hydrogelbased materials are promising candidates[2]. In this work, we are proposing the use of ionic- and photocrosslinked methacrylated gellan gum (GG-MA) hydrogels as potential acellular and cellular injectable scaffolds for IVD regeneration.

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