Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TL...

Full description

Bibliographic Details
Main Author: Carvalho, Agostinho (author)
Other Authors: Pasqualotto, A. C. (author), Pitzurra, L. (author), Romani, L (author), Denning, D. W. (author), Rodrigues, Fernando José dos Santos (author)
Format: article
Language:eng
Published: 2008
Subjects:
Aged
Aspergillosis
Aspergillosis, Allergic Bronchopulmonary
Aspergillus fumigatus
Case-Control Studies
Cohort Studies
Female
Humans
Lung Diseases, Fungal
Male
Middle Aged
Polymorphism, Single Nucleotide
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 9
Science & Technology
Online Access:http://hdl.handle.net/1822/61456
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61456
Description
Summary:Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

Similar Items