Actions of Bisnucleophiles on (E)-3-[3-(2-Hydroxyaryl)-3-oxoprop-1-en-1-yl]chromones: Versatile Transformations into Oxygen- and Nitrogen-Containing Heterocycles

The transformations of (E)-3-[3-(2-hydroxyaryl)-3-oxoprop-1-en-1-yl]chromones in the presence of methylhydrazine and aromatic bisnucleophiles are described. The reactions generally lead to chromone ring transformation via pyrone ring-opening and heterocyclization to give novel diazoles and (Z)-3-ami...

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Bibliographic Details
Main Author: Hassaine, Ridha (author)
Other Authors: Talhi, Oualid (author), Taibi, Nadia (author), Almeida Paz, Filipe A. (author), Bensaid, Okkacha (author), Bachari, Khaldoun (author), Silva, Artur M. S. (author)
Format: article
Language:eng
Published: 2017
Subjects:
SUBSTITUTED CHROMANONES
MICROWAVE IRRADIATION
DERIVATIVES
OXIDATION
HYDRAZINE
PYRAZOLES
CHROMONE
3-(3-ARYL-3-OXOPROPENYL)CHROMEN-4-ONES
PYRAZOLYL-2-PYRAZOLINES
CONDENSATION
Online Access:http://hdl.handle.net/10773/20475
Country:Portugal
Oai:oai:ria.ua.pt:10773/20475
Description
Summary:The transformations of (E)-3-[3-(2-hydroxyaryl)-3-oxoprop-1-en-1-yl]chromones in the presence of methylhydrazine and aromatic bisnucleophiles are described. The reactions generally lead to chromone ring transformation via pyrone ring-opening and heterocyclization to give novel diazoles and (Z)-3-aminomethylenechromanones, respectively. Piperazine catalyzes chromanone ring closure of the starting substrate to afford chromone-chromanone dyads.

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