Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory switch, bringing tail bud progenitors under Gdf11 signaling control. Gdf11 mutant embryos have an increased number of such progenitors that fa...

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Bibliographic Details
Main Author: Aires, Rita (author)
Other Authors: de Lemos, Luisa (author), Nóvoa, Ana (author), Jurberg, Arnon Dias (author), Mascrez, Bénédicte (author), Duboule, Denis (author), Mallo, Moisés (author)
Format: article
Language:eng
Published: 2019
Subjects:
Animals
Bone Morphogenetic Proteins
Gene Regulatory Networks
Growth Differentiation Factors
Homeodomain Proteins
Mesoderm
Mice
RNA-Binding Proteins
Signal Transduction
Stem Cells
Tail
Gene Expression Regulation, Developmental
Online Access:http://hdl.handle.net/10400.7/906
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/906

Internet

http://hdl.handle.net/10400.7/906

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