Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease

The accumulation of misfolded proteins in neurons, leading to the formation of cytoplasmic and nuclear aggregates, is a common theme in age-related neurodegenerative diseases, possibly due to disturbances of the proteostasis and insufficient activity of cellular protein clearance pathways. Lithium i...

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Bibliographic Details
Main Author: Silva, Sara Duarte (author)
Other Authors: Carvalho, Andreia Neves (author), Cunha, Carina Soares (author), Castro, Andreia Cristiana Teixeira de (author), Oliveira, Pedro (author), Fernandes, Anabela Silva (author), Maciel, P. (author)
Format: article
Language:eng
Published: 2014
Subjects:
Autophagy
Lithium
Polyglutamine
Spinocerebellar ataxia
Therapy
Triplet repeats
Science & Technology
Online Access:http://hdl.handle.net/1822/33268
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/33268

Internet

http://hdl.handle.net/1822/33268

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