Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease

Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progr...

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Detalhes bibliográficos
Autor principal: Costa, G (author)
Outros Autores: Ribeiro-Silva, C (author), Ribeiro, R (author), Gilberto, S (author), Gomes, R (author), Ferreira, A (author), Mateus, E (author), Barroso, E (author), Coelho, A (author), Ponces Freire, A (author), Cordeiro, C (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Amino Acid Sequence
HCC CHBPT
Amyloid Neuropathies, Familial/blood
Amyloid Neuropathies, Familial/metabolism
Blood Proteins/chemistry
Case-Control Studies
Electrophoresis, Gel, Two-Dimensional
Molecular Chaperones/metabolism
Molecular Sequence Data
Proteolysis
Proteomics
Sequence Homology, Amino Acid
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Texto completo:http://hdl.handle.net/10400.17/2291
País:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/2291

Texto Completo

http://hdl.handle.net/10400.17/2291

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