| Resumo: | Quetiapine (QTF) is a potent serotonin and dopamine receptor antagonist used to treat major depressive disorders and schizophrenia. A simple, precise, accurate and cost-effective titrimetric method for the determination of QTF in bulk drug and in its dosage forms has been developed and validated. The method is based on the potentiometric titration of QTF in glacial acetic acid with acetous perchloric acid using a modified glass-saturated calomel electrode system. The method is applicable over the range of 2.0 - 20.0 mg of QTF. The proposed method was successfully applied to the determination of QTF in its pharmaceutical dosage forms. The results obtained were favorably compared with those obtained using a reference method. The precision results, expressed by intra-day and inter-day relative standard deviation values, were satisfactory (RSD ≤ 1.2%). The accuracy was satisfactory as well (RE ≤ 1.33%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures, as shown by the recovery study via standard addition technique with percentage recoveries in the range 98.25-101.0 %, with a standard deviation of ≤ 0.62-1.52%.
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