Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders. A master regulator of these functions is phosphatidylinositol-3-phosphate (PI3P), a phospholipid synthesized primarily by class III PI 3-kinase Vps34. Here we report...

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Detalhes bibliográficos
Autor principal: Miranda, André Miguel Lopes (author)
Outros Autores: Lasiecka, Zofia M. (author), Xu, Yimeng (author), Neufeld, Jessi (author), Shahriar, Sanjid (author), Simoes, Sabrina (author), Chan, Robin B. (author), Oliveira, Tiago Gil (author), Small, Scott A. (author), Di Paolo, Gilbert (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Amyloid beta-Protein Precursor
Animals
Autophagy
Biomarkers
Cell Line, Tumor
Class III Phosphatidylinositol 3-Kinases
Exosomes
HEK293 Cells
Humans
Lipids
Lysophospholipids
Lysosomes
Mice, Inbred C57BL
Mice, Knockout
Monoglycerides
Neurodegenerative Diseases
Neurons
Peptide Fragments
Phosphatidylinositol Phosphates
Ciências Médicas::Medicina Básica
Science & Technology
Texto completo:http://hdl.handle.net/1822/57895
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/57895

Texto Completo

http://hdl.handle.net/1822/57895

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