Regulation of glucose uptake in mammalian cells by protein phosphorylation

Cancer cells demand increased amounts of glucose to sustain their proliferation and upregulate plasma membrane expression of glucose transporter GLUT1. In insulin responsive cells, glucose uptake requires previous phosphorylation of TBC1D4, a negative regulator of endosomal GLUT traffic. Previous wo...

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Bibliographic Details
Main Author: Henriques, Andreia (author)
Other Authors: Jordan, Peter (author)
Format: conferenceObject
Language:eng
Published: 2018
Subjects:
Vias de Transdução de Sinal e Patologias Associadas
Glucose
Cancer
Protein Phosphorylation
Online Access:http://hdl.handle.net/10400.18/5200
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5200
Description
Summary:Cancer cells demand increased amounts of glucose to sustain their proliferation and upregulate plasma membrane expression of glucose transporter GLUT1. In insulin responsive cells, glucose uptake requires previous phosphorylation of TBC1D4, a negative regulator of endosomal GLUT traffic. Previous work published by the host lab has discovered that protein kinase WNK1 can also phosphorylate TBC1D4 and promote the translocation of GLUT1 to the cell surface.

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