Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robust stability and pH sensitivity for anticancer drug delivery

The development of pH-sensitive drug delivery nanosystems that present a low drug release at the physiological pH and are able to increase the extent of the release at a lower pH value (like those existent in the interstitial space of solid tumors (pH 6.5) and in the intracellular endolysosomal comp...

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Bibliographic Details
Main Author: Wang, Guoying (author)
Other Authors: Maciel, Dina (author), Wu, Yilun (author), Rodrigues, João (author), Shi, Xiangyang (author), Yuan, Yuan (author), Liu, Changsheng (author), Tomás, Helena (author), Li, Yulin (author)
Format: article
Language:eng
Published: 2019
Subjects:
Animals
Antineoplastic agents
Cell death
Tumor
Cell shape
Cell survival
Doxorubicin
Drug liberation
Endocytosis
Humans
Hydrogen-ion concentration
Mice
Fluorescence microscopy
NIH 3T3 cells
Nanoparticles
Polymers
Silicates
Ultraviolet spectrophotometry
Fourier transform infrared spectroscopy
Surface-active agents
Drug delivery systems
.
Faculdade de Ciências Exatas e da Engenharia
Online Access:http://hdl.handle.net/10400.13/2416
Country:Portugal
Oai:oai:digituma.uma.pt:10400.13/2416

Internet

http://hdl.handle.net/10400.13/2416

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