Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications

Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs o...

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Detalhes bibliográficos
Autor principal: Brito, Alexandra Manuela Fernandes (author)
Outros Autores: Kassem, Salma (author), Reis, R. L. (author), Ulijn, Rein V. (author), Pires, R. A. (author), Pashkuleva, I. (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Glycoconjugate
Glycolipid
Glycopeptide
Hydrogel
Multivalency
Self-assembly
Systems chemistry
SDG3: Good health and well-being
Science & Technology
Texto completo:http://hdl.handle.net/1822/73000
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73000
Descrição
Resumo:Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.

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