Proteasome inhibition prevents cell death induced by the chemotherapeutic agent cisplatin downstream of DNA damage

Cisplatin is a highly effective chemotherapeutic drug acting as a DNA-damaging agent that induces apoptosis of rapidly proliferating cells. Unfortunately, cellular resistance still occurs. Mutations in p53 in a large fraction of tumor cells contribute to defects in apoptotic pathways and drug resist...

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Bibliographic Details
Main Author: Costa, Ana Rita Martins (author)
Other Authors: Machado, Nuno (author), Rego, António (author), Sousa, Maria João (author), Côrte-Real, Manuela (author), Chaves, Susana Alexandra Rodrigues (author)
Format: article
Language:eng
Published: 2019
Subjects:
Apoptosis
Cell Cycle Checkpoints
Cisplatin
DNA Repair
Proteasome Inhibitors
Saccharomyces cerevisiae
DNA Damage
Yeast
Proteasome
Regulated cell death
Cancer
Chemotherapy
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/72840
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/72840

Internet

http://hdl.handle.net/1822/72840

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