Co-delivery of two anti-HIV drug nanocrystals from electrospun nanofibers

TRUVADA is the only medication approved by FDA for pre-exposure prophylaxis of the HIV infection. They are tablets with fixed dosages of two antiretroviral compounds for daily oral uptake: Tenofovir disoproxil fumarate (TDF) and Emtricitabine (EMT) that are reverse transcriptase inhibitors. Objectiv...

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Bibliographic Details
Main Author: Malta, Rafaela (author)
Other Authors: Neves, José das (author), Sarmento, Bruno (author), Machado, Raul (author), Lúcio, M. (author), Viseu, T. M. R. (author)
Format: conferencePoster
Language:eng
Published: 2017
Subjects:
HIV infection
Tenofovir disoproxil fumarate (TDF)
Emtricitabine (EMT)
Electrospinning
Polymeric nanofibers
Controled drug delivery
Ciências Médicas::Ciências da Saúde
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Ciências Naturais::Ciências Químicas
Ciências Naturais::Ciências Biológicas
Engenharia e Tecnologia::Engenharia Química
Engenharia e Tecnologia::Engenharia dos Materiais
Online Access:http://hdl.handle.net/1822/55615
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/55615
Description
Summary:TRUVADA is the only medication approved by FDA for pre-exposure prophylaxis of the HIV infection. They are tablets with fixed dosages of two antiretroviral compounds for daily oral uptake: Tenofovir disoproxil fumarate (TDF) and Emtricitabine (EMT) that are reverse transcriptase inhibitors. Objectives:  Incorporate TDF and EMT drugs in polymeric nanofibers produced by electrospinning; chosen polymers were polyoxyethilene (PEO) and polycaprolactone (PCL). Characterize the nanofibers and study the in vitro release profile of the drugs. Evaluate the possibility of a topical administration of the loaded fibers , by rectal or genital route, for HIV infection prophylaxis.

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