Fast setting silk fibroin bioink for bioprinting of patient-specific memory-shape implants

The pursuit for the â perfectâ biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroi...

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Detalhes bibliográficos
Autor principal: Costa, João B. (author)
Outros Autores: Silva-Correia, Joana (author), Oliveira, J. M. (author), Reis, R. L. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Texto completo:http://hdl.handle.net/1822/48157
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/48157
Descrição
Resumo:The pursuit for the â perfectâ biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology.