The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

Cyclosporin A (CsA), tacrolimus and rapamycin are immunosuppressive agents (IAs) associated with insulin resistance and dyslipidemia, although their molecular effects on lipid metabolism in adipose tissue are unknown. We explored IAs effects on lipolysis, lipid storage and expression of genes involv...

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Bibliographic Details
Main Author: Pereira, Maria João (author)
Other Authors: Palming, Jenny (author), Rizell, Magnus (author), Aureliano, M. (author), Carvalho, Eugénia (author), Svensson, Maria K. (author), Eriksson, Jan W. (author)
Format: article
Language:eng
Published: 2013
Subjects:
Cyclosporin A
Rapamycin
Tacrolimus
Lipolysis
Adipocytes
Lipid storage
Online Access:http://hdl.handle.net/10400.1/2066
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/2066

Internet

http://hdl.handle.net/10400.1/2066

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