New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screen...

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Bibliographic Details
Main Author: Lobo, Lis (author)
Other Authors: Cabral, Lília I.L. (author), Sena, Maria Inês (author), Guerreiro, Bruno (author), Rodrigues, António Sebastião (author), De Andrade-Neto, Valter Ferreira (author), Cristiano, Maria L.S. (author), Nogueira, Fatima (author)
Format: article
Language:eng
Published: 2021
Subjects:
Antimalarial drug resistance
In vivo antimalarial activity
Plasmodium falciparum
Tetraoxane-tetrazole conjugates
Trioxolane-tetrazole conjugates
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/116839
Country:Portugal
Oai:oai:run.unl.pt:10362/116839

Internet

http://hdl.handle.net/10362/116839

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