Pyrrolidine-based amino alcohols: novel ligands for the enantioselective alkylation of benzaldehyde

A series of easily obtained pyrrolidine-based [beta]-amino alcohols derived from tartaric acid and primary amines was synthesized and used as chiral ligands in the enantioselective alkylation of benzaldehyde. Using diethylzinc, 1-phenyl-1-propanol was obtained with enantiomeric excesses of up to 80%...

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Bibliographic Details
Main Author: Gonsalves, António M. d'. A. Rocha (author)
Other Authors: Serra, M. Elisa S. (author), Murtinho, Dina (author), Silva, Vitor F. (author), Beja, A. Matos (author), Paixão, J. A. (author), Silva, M. Ramos (author), Veiga, L. Alte da (author)
Format: article
Language:eng
Published: 2003
Subjects:
Enantioselective alkylation
[beta]-Amino alcohols
Diethylzinc
Pyrrolidinoalcohols
Benzaldehyde
Online Access:http://hdl.handle.net/10316/5168
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5168

Internet

http://hdl.handle.net/10316/5168

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