Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical for amyloid fibril formation and disease develo...

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Bibliographic Details
Main Author: Frangolho, Ana (author)
Other Authors: Correia, Bruno E. (author), Vaz, Daniela C. (author), Almeida, Zaida L. (author), Brito, Rui M. M. (author)
Format: article
Language:eng
Published: 2020
Subjects:
Transthyretin
TTR
TTR variants
Amyloidosis
ATTR
Linear oligomerization
Downhill polymerization
Aggregation
Amyloid
Online Access:http://hdl.handle.net/10400.8/5230
Country:Portugal
Oai:oai:iconline.ipleiria.pt:10400.8/5230

Internet

http://hdl.handle.net/10400.8/5230

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