Differential effect of valproate and its Delta(2)- and Delta(4)-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids

Overall fatty acid oxidation rates were investigated in rat hepatocytes using [9,10-H-3]palmitic, [9,10-H-3]-oleic, [9.10-H-3]-myristic and [2,3-H-3]-phenylpropionic acids. The effect of both valproate (VPA) (0-10 mM) and two of its unsaturated metabolite

Detalhes bibliográficos
Autor principal: Silva, MFB (author)
Outros Autores: Ruiter, JPN (author), IJlst, L (author), Jakobs, C (author), Duran, M (author), de Almeida, IT (author), Wanders, RJA (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemistry & Molecular Biology
Pharmacology & Pharmacy
Toxicology
Texto completo:http://hdl.handle.net/10451/21331
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21331
Descrição
Resumo:Overall fatty acid oxidation rates were investigated in rat hepatocytes using [9,10-H-3]palmitic, [9,10-H-3]-oleic, [9.10-H-3]-myristic and [2,3-H-3]-phenylpropionic acids. The effect of both valproate (VPA) (0-10 mM) and two of its unsaturated metabolite

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