Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ sila...

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Bibliographic Details
Main Author: Moreira, André Ferreira (author)
Other Authors: Rodrigues, Ana Carolina Félix (author), Reis, Ana Catarina Almeida (author), Costa, Elisabete Cristina da Rocha (author), Ferreira, Paula (author), Correia, Ilídio Joaquim Sobreira (author)
Format: article
Language:eng
Published: 2018
Subjects:
Cancer
Combinatorial therapy
Drug-delivery
Gold-core silica shell nanorods
Photothermal therapy
Online Access:http://hdl.handle.net/10400.6/6609
Country:Portugal
Oai:oai:ubibliorum.ubi.pt:10400.6/6609
Description
Summary:Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.

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