Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells

In the present work, novel chromene derivatives fused with the imidazo[1,2-a]pyridine nucleus were tested for their anticancer potential in the human colorectal cancer HCT116 cells. Compounds 2a and 2c showed significant growth inhibitory activity with GI50 of 15 mu M and 11 mu M, respectively. Comp...

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Bibliographic Details
Main Author: Lima, Cristóvão Fernando Macedo (author)
Other Authors: Costa, Marta (author), Proença, M. Fernanda R. P. (author), Pereira-Wilson, Cristina (author)
Format: article
Language:eng
Published: 2015
Subjects:
HCT116 cancer cells
Cytotoxicity
P53
Apoptosis
Chromene derivatives
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/49909
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/49909

Internet

http://hdl.handle.net/1822/49909

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