Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have previously reported that mRNAs containing PTCs in...

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Detalhes bibliográficos
Autor principal: Peixeiro, Isabel (author)
Outros Autores: Inácio, Ângela (author), Barbosa, Cristina (author), Silva, Ana Luísa (author), Liebhaber, Stephen (author), Romão, Luísa (author)
Formato: article
Idioma:eng
Publicado em: 2011
Assuntos:
Mammalian nonsense-mediated mRNA decay (NMD)
Translation initiation
AUG-proximal nonsense-mutated mRNAs
Poly(A)-binding protein (PABP)
Premature termination codon (PTC)
Genética funcional e estrutural
Texto completo:http://hdl.handle.net/10400.18/334
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/334

Texto Completo

http://hdl.handle.net/10400.18/334

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