The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion
The presence of a leaving group at C- 4 of monobactams is usually considered to be a requirement for mechanism- based inhibition of human leukocyte elastase by these acylating agents. We report that second- order rate constants for the alkaline hydrolysis and elastase inactivation by N- carbamoyl mo...
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| Other Authors: | , , , , |
| Format: | article |
| Language: | eng |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10451/21522 |
| Country: | Portugal |
| Oai: | oai:repositorio.ul.pt:10451/21522 |