Studies on the extra-mitochondrial CoA-ester formation of valproic and Delta(4)-valproic acids

The hypothesis whether valproic acid (VPA) and its main microsomal metabolite, Delta(4) -valproic acid, can be activated to the respective CoA esters in the cell cytosol was investigated. The valproyl-CoA formation was measured in different subcellular fr

Bibliographic Details
Main Author: Aires, Catia C. P. (author)
Other Authors: Ruiter, Jos P. N. (author), Luis, Paula B. M. (author), ten Brink, Herman J. (author), Ijlst, Lodewijk (author), de Almeida, Isabel Tavares (author), Duran, Marinus (author), Wanders, Ronald J. A. (author), Silva, Margarida F. B. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Biochemistry & Molecular Biology
Biophysics
Cell Biology
Online Access:http://hdl.handle.net/10451/21620
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21620
Description
Summary:The hypothesis whether valproic acid (VPA) and its main microsomal metabolite, Delta(4) -valproic acid, can be activated to the respective CoA esters in the cell cytosol was investigated. The valproyl-CoA formation was measured in different subcellular fr

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