Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) Amino Acid 1466 associated with resistance to Sulfadoxine-Pyrimethamine treatment

Sulfadoxine-pyrimethamine (SP) remains widely recommended for intermittent preventive treatment against Plasmodium falciparum malaria for pregnant women and infants in Africa. Resistance to SP is increasing and associated primarily with mutations in the P. falciparum dhfr (Pfdhfr) and Pfdhps genes....

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Bibliographic Details
Main Author: Dahlstrom, Sabina (author)
Other Authors: Veiga, M. Isabel (author), Martensson, Andreas (author), Bjorkman, Anders (author), Gil, J. P. (author)
Format: article
Language:eng
Published: 2018
Subjects:
Antifolate resistance
Dihydropteroate-Synthetase
Dihydrofolate-reductase
Malaria
Folate
Mrp1
Chemotherapy
Expression
Mutations
Transport
Online Access:http://hdl.handle.net/10400.1/11572
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11572

Internet

http://hdl.handle.net/10400.1/11572

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