Preclinical pharmacokinetics and biodistribution of anticancer dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in mice

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro...

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Bibliographic Details
Main Author: Vojtek, Martin (author)
Other Authors: Gonçalves-Monteiro, Salomé (author), Pinto, Edgar (author), Kalivodová, Sára (author), Almeida, Agostinho (author), Marques, Maria P. M. (author), Batista de Carvalho, Ana L. M. (author), Martins, Clara B. (author), Mota-Filipe, Helder (author), Ferreira, Isabel M. P. L. V. O. (author), Diniz, Carmen (author)
Format: article
Language:eng
Published: 2021
Subjects:
Pd(II)-based drugs
Cisplatin ICP-MS
Metal complexes
Polyamines
Cancer
Tissue
In vivo
Online Access:http://hdl.handle.net/10400.22/17801
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/17801

Internet

http://hdl.handle.net/10400.22/17801

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