Catechols from abietic acid

Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of ca...

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Detalhes bibliográficos
Autor principal: Gigante, B (author)
Outros Autores: Santos, C (author), Silva, AM (author), Curto, MJM (author), Nascimento, MSJ (author), Pinto, E (author), Pedro, M (author), Cerqueira, F (author), Pinto, MM (author), Duarte, MP (author), Laires, A (author), Rueff, J (author), Goncalves, J (author), Pegado, MI (author), Valdeira, ML (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemistry & Molecular Biology
Chemistry, Medicinal
Chemistry, Organic
Texto completo:http://hdl.handle.net/10451/21265
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21265
Descrição
Resumo:Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid. (C) 2003 Elsevier Science Ltd. All rights reserved.

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