Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction
Aim Chalcones are naturally occurring compounds with recognized anticancer activity. It was recently shown that the O-prenyl derivative (2) of 2-hydroxy-3,4,4,5,6-pentamethoxychalcone (1) had a remarkably increased cytotoxicity against human tumour cells compared to its precursor. With this study, w...
| Autor principal: | |
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| Outros Autores: | , , , , , , , , , , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2015
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| Texto completo: | https://repositorio-aberto.up.pt/handle/10216/91106 |
| País: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/91106 |