Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen

This study evaluated the effect of the synthetic, nonsteroidal antiestrogen drug tamoxifen on the function of brain mitochondria. We observed that tamoxifen concentrations above 30 nmol/mg protein induced a slight decrease on RCR and ADP/O ratio. However, only higher concentrations of tamoxifen (>...

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Detalhes bibliográficos
Autor principal: Moreira, Paula I. (author)
Outros Autores: Custódio, José B. (author), Oliveira, Catarina R. (author), Santos, Maria S. (author)
Formato: article
Idioma:eng
Publicado em: 2005
Assuntos:
Mitochondria
Neuroprotection
Oxidative stress
Tamoxifen
Texto completo:http://hdl.handle.net/10316/5372
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5372

Texto Completo

http://hdl.handle.net/10316/5372

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