Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen

This study evaluated the effect of the synthetic, nonsteroidal antiestrogen drug tamoxifen on the function of brain mitochondria. We observed that tamoxifen concentrations above 30 nmol/mg protein induced a slight decrease on RCR and ADP/O ratio. However, only higher concentrations of tamoxifen (>...

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Bibliographic Details
Main Author: Moreira, Paula I. (author)
Other Authors: Custódio, José B. (author), Oliveira, Catarina R. (author), Santos, Maria S. (author)
Format: article
Language:eng
Published: 2005
Subjects:
Mitochondria
Neuroprotection
Oxidative stress
Tamoxifen
Online Access:http://hdl.handle.net/10316/5372
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5372

Internet

http://hdl.handle.net/10316/5372

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