The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin
Transthyretin (TTR) is a homotetrameric protein implicated in several amyloid diseases. The mechanism by which TTR is converted into elongated fibrillar assemblies has been extensively investigated, and numerous studies showed that dissociation of the native tetrameric structure into partially unfol...
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| Other Authors: | , , |
| Format: | article |
| Language: | eng |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10400.8/4261 |
| Country: | Portugal |
| Oai: | oai:iconline.ipleiria.pt:10400.8/4261 |