Optimisation Methods for Improving Fed-batch Cultivation of E. Coli Producing Recombinant Proteins

Two optimisation techniques for the fed-batch cultivation of high cell density Escherichia coli producing recombinant proteins were compared. An unstructured model for the growth, based on the General State Space Dynamical Model [1] was used to represent the four major metabolic pathways: oxidative...

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Bibliographic Details
Main Author: Rocha, I. (author)
Other Authors: Ferreira, Eugénio C. (author)
Format: conferencePaper
Language:eng
Published: 2002
Subjects:
Optimisation
Fed-batch fermentation
E. coli
Gradient methods
Genetic algorithms
Online Access:https://hdl.handle.net/1822/129
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/129

Internet

https://hdl.handle.net/1822/129

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